Diacetylmorphine for Adults With Opioid Dependence


 Injectable diacetylmorphine might provide more benefits and lower costs compared with oral methadone maintenance therapy in patients severe opioid use disorder.
 The Canadian Research Initiative Substance Misuse guideline recommends that both injectable hydromorphone should be considered as treatment options for individuals severe, treatment-refractory disorder ongoing illicit injection use, the agonist have an end date to transition treatment.
 No recent studies on clinical effectiveness of comparison or buprenorphine were identified.
 cost-effectiveness